Bringing a super-sized canine back from extinction after 12,500 years might sound like the plot of a blockbuster movie featuring special effects with gnawed flesh and buckets of fake intestines, but it's become a reality. Thanks to the efforts of Colossal Biosciences, the world now has three dire wolves living in a secret location in the US.
Romulus and Remus at three months old
The biotech company behind this project used DNA from the common gray wolf, gene-editing techniques, and domestic dog surrogates to bring Romulus, Remus, and their younger sister, Khaleesi, into existence. These dire wolves are exactly what any mother of dragons would envision: huge, white, and simply awe-inspiring.
“I could not be more proud of the team. This massive milestone is the first of many coming examples demonstrating that our end-to-end de-extinction technology stack works,” said Ben Lamm, CEO of Colossal.
“Our team took DNA from a 13,000-year-old tooth and a 72,000-year-old skull and made healthy dire wolf puppies. It was once said, ‘any sufficiently advanced technology is indistinguishable from magic.’ Today, our team gets to unveil some of the magic they are working on and its broader impact on conservation.”
Romulus and Remus at one month old
This isn't the first time Colossal Biosciences has made headlines; they previously engineered a Colossal Woolly Mouse, resembling a mammoth phenotype, using computational analysis of 59 woolly, Columbian, and steppe mammoth genomes ranging from 3,500 to over 1,200,000 years old. Critics argue that these dire wolves are the genetic equivalent of normal wolves in fancy dress, suggesting that the dire wolf DNA available today isn't sufficient for a true genetic clone.
Colossal Biosciences' motives go beyond creating social media buzz and owning extraordinary pets. The company aims to use its findings to help preserve current species for future generations.
“The de-extinction of the dire wolf and an end-to-end system for de-extinction is transformative and heralds an entirely new era of human stewardship of life,” said Dr. Christopher Mason, a scientific advisor and member of the board of observers for Colossal.
“The same technologies that created the dire wolf can directly help save a variety of other endangered animals as well. This is an extraordinary technological leap in genetic engineering efforts for both science and for conservation as well as preservation of life, and a wonderful example of the power of biotechnology to protect species, both extant and extinct.”
Colossal Biosciences has collaborated with the American Humane Society and the USDA to ensure that its 2,000+ acre preserve, where the dire wolves reside, meets high standards. These superstars are cared for by a dedicated team of staff, ensuring their well-being and the success of this groundbreaking project.